Celgosivir
Modify Date: 2024-01-21 21:47:05
Celgosivir structure
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Common Name | Celgosivir | ||
|---|---|---|---|---|
| CAS Number | 121104-96-9 | Molecular Weight | 259.299 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 422.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H21NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 209.6±28.7 °C | |
Use of CelgosivirCelgosivir (MBI 3253; MDL 28574; MX3253) is a novel α-glucosidase I inhibitor, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins.[1] |
| Name | [(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Celgosivir (MBI 3253; MDL 28574; MX3253) is a novel α-glucosidase I inhibitor, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins.[1] |
|---|---|
| Related Catalog | |
| Target |
IC50: 16 and 47 umol/L (alpha-glucosidase I, Using plaque assay and a cytopathic assay)[2] |
| In Vitro | The quantity of THP-1 cells is 1 × 105 , cells were washed once with media and replaced with 500 μl with a serial 4-fold dilution starting from 200 μM or 50 μM.[3] |
| In Vivo | Celgosivir, stored at 100 mg/ml in PBS at 30 °C, were diluted with PBS before each dosing to obtain 1 mg/200 μl (50 mg/kg) or 0.2 mg/200 μl (10 mg/kg). [3] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 422.9±45.0 °C at 760 mmHg |
| Molecular Formula | C12H21NO5 |
| Molecular Weight | 259.299 |
| Flash Point | 209.6±28.7 °C |
| Exact Mass | 259.141968 |
| PSA | 90.23000 |
| LogP | -0.82 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.569 |
| Storage condition | 2-8℃ |
|
~%
Celgosivir CAS#:121104-96-9 |
| Literature: Liu; Hoekstra; King Tetrahedron Letters, 1990 , vol. 31, # 20 p. 2829 - 2832 |
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~%
Celgosivir CAS#:121104-96-9 |
| Literature: Anderson, Wayne K.; Coburn, Robert A.; Gopalsamy, Ariamala; Howe, Trevor J. Tetrahedron Letters, 1990 , vol. 31, # 2 p. 169 - 170 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 6-O-butanoylcastanospermine |
| UNII:895VG117HN |
| BuCast |
| (1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydro-6-indolizinyl butyrate |
| MX-3253 |
| B-T |
| 6-O-Butyryltanosopermine |
| 6-O-Butanoyltanospermine |
| Butanoic Acid (1S,6S,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinyl Ester |
| [(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate |
| MDL 28,574 |
| UNII-895VG117HN |
| 6-O-butyryltanospermine |
| (1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydroindolizin-6-yl butyrate |
| Butanoic acid, (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester |
| Celgosivir |