Celgosivir

Modify Date: 2024-01-21 21:47:05

Celgosivir structure	Common Name	Celgosivir
	CAS Number	121104-96-9	Molecular Weight	259.299
	Density	1.3±0.1 g/cm3	Boiling Point	422.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₂₁NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	209.6±28.7 °C

Use of Celgosivir

Celgosivir (MBI 3253; MDL 28574; MX3253) is a novel α-glucosidase I inhibitor, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins.[1]

Name	[(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate
Synonym	More Synonyms

Description	Celgosivir (MBI 3253; MDL 28574; MX3253) is a novel α-glucosidase I inhibitor, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins.[1]
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Natural Products >> Alkaloid Research Areas >> Infection
Target	IC50: 16 and 47 umol/L (alpha-glucosidase I, Using plaque assay and a cytopathic assay)[2]
In Vitro	The quantity of THP-1 cells is 1 × 105 , cells were washed once with media and replaced with 500 μl with a serial 4-fold dilution starting from 200 μM or 50 μM.[3]
In Vivo	Celgosivir, stored at 100 mg/ml in PBS at 30 °C, were diluted with PBS before each dosing to obtain 1 mg/200 μl (50 mg/kg) or 0.2 mg/200 μl (10 mg/kg). [3]
References	[1]. Durantel D. Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. Curr Opin Investig Drugs. 2009 Aug, 10(8):860-70. [2]. Whitby K et al. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for thetreatment of hepatitis C. Antivir Chem Chemother, 2004 May, 15(3):141-51. [3]. Satoru Watanabe，Kitti Wing-Ki Chan et al. Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy. Antiviral Research, March 2016, Pages 10-19.

Density	1.3±0.1 g/cm3
Boiling Point	422.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₂₁NO₅
Molecular Weight	259.299
Flash Point	209.6±28.7 °C
Exact Mass	259.141968
PSA	90.23000
LogP	-0.82
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.569
Storage condition	2-8℃

Castanospermine

CAS#:79831-76-8

Celgosivir

CAS#:121104-96-9

Literature: Liu; Hoekstra; King Tetrahedron Letters, 1990 , vol. 31, # 20 p. 2829 - 2832

Castanospermine

CAS#:79831-76-8

Butyryl chloride

CAS#:141-75-3

Celgosivir

CAS#:121104-96-9

Literature: Anderson, Wayne K.; Coburn, Robert A.; Gopalsamy, Ariamala; Howe, Trevor J. Tetrahedron Letters, 1990 , vol. 31, # 2 p. 169 - 170

Precursor 2
CAS#:79831-76-8 Castanospermine CAS#:141-75-3 Butyryl chloride
DownStream 0

6-O-butanoylcastanospermine

UNII:895VG117HN

BuCast

(1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydro-6-indolizinyl butyrate

MX-3253

B-T

6-O-Butyryltanosopermine

6-O-Butanoyltanospermine

Butanoic Acid (1S,6S,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinyl Ester

[(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate

MDL 28,574

UNII-895VG117HN

6-O-butyryltanospermine

(1S,6S,7S,8R,8aR)-1,7,8-Trihydroxyoctahydroindolizin-6-yl butyrate

Butanoic acid, (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester

Celgosivir

DC Chemicals Limited
China
Product Name: 60-P-001
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $180/1mg

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Celgosivir

Use of Celgosivir

Names

Celgosivir Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms