18-Deoxyherboxidiene

Modify Date: 2025-08-25 12:07:18

18-Deoxyherboxidiene Structure
18-Deoxyherboxidiene structure
Common Name 18-Deoxyherboxidiene
CAS Number 1200128-66-0 Molecular Weight 422.598
Density 1.0±0.1 g/cm3 Boiling Point 525.2±30.0 °C at 760 mmHg
Molecular Formula C25H42O5 Melting Point N/A
MSDS N/A Flash Point 165.7±18.1 °C

 Use of 18-Deoxyherboxidiene


18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].

 Names

Name 18-Deoxyherboxidiene
Synonym More Synonyms

 18-Deoxyherboxidiene Biological Activity

Description 18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].
Related Catalog
References

[1]. Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo). 2016 Feb;69(2):121-3.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 525.2±30.0 °C at 760 mmHg
Molecular Formula C25H42O5
Molecular Weight 422.598
Flash Point 165.7±18.1 °C
Exact Mass 422.303223
LogP 4.21
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.487

 Synonyms

{(2R,5S,6S)-6-[(2E,4E,6S)-7-{(2R,3R)-3-[(2R,3S)-3-Methoxy-2-pentanyl]-2-methyl-2-oxiranyl}-6-methyl-2,4-heptadien-2-yl]-5-methyltetrahydro-2H-pyran-2-yl}acetic acid
2H-Pyran-2-acetic acid, tetrahydro-6-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-methoxy-1-methylbutyl]-2-methyloxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-5-methyl-, (2R,5S,6S)-
18-Deoxyherboxidiene
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