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18-Deoxyherboxidiene

Names

[ CAS No. ]:
1200128-66-0

[ Name ]:
18-Deoxyherboxidiene

[Synonym ]:
{(2R,5S,6S)-6-[(2E,4E,6S)-7-{(2R,3R)-3-[(2R,3S)-3-Methoxy-2-pentanyl]-2-methyl-2-oxiranyl}-6-methyl-2,4-heptadien-2-yl]-5-methyltetrahydro-2H-pyran-2-yl}acetic acid
2H-Pyran-2-acetic acid, tetrahydro-6-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-methoxy-1-methylbutyl]-2-methyloxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-5-methyl-, (2R,5S,6S)-
18-Deoxyherboxidiene

Biological Activity

[Description]:

18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Hideaki Kakeya, et al. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis. J Antibiot (Tokyo). 2016 Feb;69(2):121-3.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
525.2±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H42O5

[ Molecular Weight ]:
422.598

[ Flash Point ]:
165.7±18.1 °C

[ Exact Mass ]:
422.303223

[ LogP ]:
4.21

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.487

Related Compounds

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