NT219

Modify Date: 2025-08-25 11:32:35

NT219 structure	Common Name	NT219
	CAS Number	1198078-60-2	Molecular Weight	412.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄BrNO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NT219

NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases[1].

Name	NT219

Description	NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
References	[1]. Alberto Bessudo, et al. A phase 1/2 study with open-label, dose escalation phase followed by single-arm expansion at the maximum tolerated dose to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of NT219 injection alone and in combination with cetuximab in adults with advanced solid tumors and head and neck cancer.

Molecular Formula	C₁₆H₁₄BrNO₅S
Molecular Weight	412.26
InChIKey	XDDQKKXXQHUUHJ-DUXPYHPUSA-N
SMILES	Oc1cc(CNC(=S)C=Cc2ccc(O)c(O)c2Br)cc(O)c1O

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NT219
Price: Check
Purity: 99.72%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NT219
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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NT219

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.