1198078-60-2

1198078-60-2 structure

Name: NT219
Chemical Name: NT219
CAS Number: 1198078-60-2
Molecular Formula: C₁₆H₁₄BrNO₅S
Molecular Weight: 412.26
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2022-05-21 17:39:35
Modify Date: 2024-01-12 06:44:21
NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases[1].

Name	NT219

Description	NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
References	[1]. Alberto Bessudo, et al. A phase 1/2 study with open-label, dose escalation phase followed by single-arm expansion at the maximum tolerated dose to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of NT219 injection alone and in combination with cetuximab in adults with advanced solid tumors and head and neck cancer.

Molecular Formula	C₁₆H₁₄BrNO₅S
Molecular Weight	412.26