CRANAD-2

Modify Date: 2025-08-25 16:51:15

CRANAD-2 Structure
CRANAD-2 structure
Common Name CRANAD-2
CAS Number 1193447-34-5 Molecular Weight 410.26500
Density N/A Boiling Point N/A
Molecular Formula C23H25BF2N2O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of CRANAD-2


CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].

 Names

Name CRANAD-2
Synonym More Synonyms

 CRANAD-2 Biological Activity

Description CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].
Related Catalog
References

[1]. Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131(42):15257-61.

[2]. Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6(4):e19362.

 Chemical & Physical Properties

Molecular Formula C23H25BF2N2O2
Molecular Weight 410.26500
Exact Mass 410.19800
PSA 32.78000
LogP 4.93870
InChIKey PVXQJYXODFZTBR-UHFFFAOYSA-N
SMILES CN(C)c1ccc(C=CC2=CC(=CC=C3C=CC(=[N+](C)C)C=C3)O[B-](F)(F)O2)cc1
Storage condition 2-8°C
Water Solubility DMSO: soluble 0.2 mg/mL, clear (warmed)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synonyms

(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron
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