Remdesivir O-desphosphate acetonide impurity

Modify Date: 2024-01-06 19:15:02

Remdesivir O-desphosphate acetonide impurity Structure
Remdesivir O-desphosphate acetonide impurity structure
Common Name Remdesivir O-desphosphate acetonide impurity
CAS Number 1191237-80-5 Molecular Weight 331.13
Density N/A Boiling Point N/A
Molecular Formula C15H17N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Remdesivir O-desphosphate acetonide impurity


Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

 Names

Name D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-
Synonym More Synonyms

  Biological Activity

Description Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].
Related Catalog
In Vitro Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir[1].
References

[1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.

[2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

 Chemical & Physical Properties

Molecular Formula C15H17N5O4
Molecular Weight 331.13

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD32693253