Trofosfamide-d4

Modify Date: 2024-01-14 15:58:16

Trofosfamide-d4 Structure
Trofosfamide-d4 structure
Common Name Trofosfamide-d4
CAS Number 1189884-36-3 Molecular Weight 327.60900
Density N/A Boiling Point N/A
Molecular Formula C9H14Cl3D4N2O2P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Trofosfamide-d4


Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1][2].

 Names

Name Trofosfamide
Synonym More Synonyms

 Trofosfamide-d4 Biological Activity

Description Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.

[3]. Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

 Chemical & Physical Properties

Molecular Formula C9H14Cl3D4N2O2P
Molecular Weight 327.60900
Exact Mass 326.04200
PSA 42.59000
LogP 2.77310

 Synonyms

N,N,3-tris(2-chloroethyl)-4,4,5,5-tetradeuterio-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-2-amine
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