Trofosfamide-d4

Names

[ Name ]:
Trofosfamide-d4

[Synonym ]:
N,N,3-tris(2-chloroethyl)-4,4,5,5-tetradeuterio-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-2-amine

Biological Activity

[Description]:

Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.

[3]. Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₄Cl₃D₄N₂O₂P

[ Molecular Weight ]:
327.60900

[ Exact Mass ]:
326.04200

[ PSA ]:
42.59000

[ LogP ]:
2.77310

Related Compounds

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