TMN 355
Modify Date: 2025-08-26 18:47:50
TMN 355 structure
|
Common Name | TMN 355 | ||
|---|---|---|---|---|
| CAS Number | 1186372-20-2 | Molecular Weight | 380.79900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H14ClFN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TMN 355TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1]. |
| Name | 1-(2-chloro-6-fluorobenzoyl)-3-(9H-fluoren-9-yl)-urea |
|---|---|
| Synonym | More Synonyms |
| Description | TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1]. |
|---|---|
| Related Catalog | |
| Target |
cyclophilin A[1] |
| In Vitro | TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: THP cell lines Concentration: 0.5, 1, 2.5, 5 and 10 μM Incubation Time: 3, 6 and 9 hours Result: Resulted in 75.9% reduction of cyclophilin A protein expression. |
| References |
| Molecular Formula | C21H14ClFN2O2 |
|---|---|
| Molecular Weight | 380.79900 |
| Exact Mass | 380.07300 |
| PSA | 58.20000 |
| LogP | 5.47030 |
| InChIKey | SFNLLCUAISZNRV-UHFFFAOYSA-N |
| SMILES | O=C(NC(=O)c1c(F)cccc1Cl)NC1c2ccccc2-c2ccccc21 |
| Hazard Codes | Xi |
|---|
| 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide |