TMN 355

Modify Date: 2025-08-26 18:47:50

TMN 355 Structure
TMN 355 structure
Common Name TMN 355
CAS Number 1186372-20-2 Molecular Weight 380.79900
Density N/A Boiling Point N/A
Molecular Formula C21H14ClFN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TMN 355


TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].

 Names

Name 1-(2-chloro-6-fluorobenzoyl)-3-(9H-fluoren-9-yl)-urea
Synonym More Synonyms

 TMN 355 Biological Activity

Description TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].
Related Catalog
Target

cyclophilin A[1]

In Vitro TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: THP cell lines Concentration: 0.5, 1, 2.5, 5 and 10 μM Incubation Time: 3, 6 and 9 hours Result: Resulted in 75.9% reduction of cyclophilin A protein expression.
References

[1]. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.

 Chemical & Physical Properties

Molecular Formula C21H14ClFN2O2
Molecular Weight 380.79900
Exact Mass 380.07300
PSA 58.20000
LogP 5.47030
InChIKey SFNLLCUAISZNRV-UHFFFAOYSA-N
SMILES O=C(NC(=O)c1c(F)cccc1Cl)NC1c2ccccc2-c2ccccc21

 Safety Information

Hazard Codes Xi

 Synonyms

2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
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