Flumequine-13C3

Modify Date: 2024-01-09 19:30:29

Flumequine-13C3 structure	Common Name	Flumequine-13C3
	CAS Number	1185049-09-5	Molecular Weight	264.226
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₁₁₃C₃H₁₂FNO₃	Melting Point	253-255°C
	MSDS	USA	Flash Point	N/A

Use of Flumequine-13C3

Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

Name	9-Fluoro-5-methyl-1-oxo(1,2-13C2)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-(13C)carboxylic acid
Synonym	More Synonyms

Description	Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Kashida Y, et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69(2):317-21. [3]. Aller-Morán LM, et al. Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3. [4]. Giraud E, et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53(Pt 9):895-901.

Density	1.5±0.1 g/cm3
Melting Point	253-255°C
Molecular Formula	C₁₁₁₃C₃H₁₂FNO₃
Molecular Weight	264.226
Exact Mass	264.090179
Index of Refraction	1.646
Storage condition	-20°C Freezer

RIDADR	NONH for all modes of transport

9-Fluoro-5-methyl-1-oxo(1,2-13C2)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-(13C)carboxylic acid

1H,5H-Benzo[ij]quinolizine-1,2-13C2-2-carboxylic-13C acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo-

Flumequine-13C3

Use of Flumequine-13C3

Names

Flumequine-13C3 Biological Activity

Chemical & Physical Properties

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