Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt

Modify Date: 2024-01-09 09:48:45

Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt Structure
Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt structure
Common Name Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt
CAS Number 118253-05-7 Molecular Weight 587.71
Density N/A Boiling Point N/A
Molecular Formula C34H41N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt


Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner[1].

 Names

Name [(3S)-7-amino-2-oxo-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]heptyl] 2,4,6-trimethylbenzoate,2,2,2-trifluoroacetic acid
Synonym More Synonyms

  Biological Activity

Description Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner[1].
Related Catalog
References

[1]. Imamura T, et, al. Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites. Infect Immun. 1995 Dec;63(12):4877-82.  

 Chemical & Physical Properties

Molecular Formula C34H41N3O6
Molecular Weight 587.71
Exact Mass 623.27600
PSA 136.82000
LogP 6.77330

 Synonyms

(S)-7-Amino-3-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-2-oxoheptyl 2,4,6-trimethylbenzoate 2,2,2-trifluoroacetate