ML358
Modify Date: 2025-11-30 19:38:53
ML358 structure
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Common Name | ML358 | ||
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| CAS Number | 1158607-44-3 | Molecular Weight | 430.796 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H26Cl3NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML358ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo. |
| Name | N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo. |
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| References | References 1. Peddibhotla S, et al. ACS Chem Biol. 2015 Aug 21;10(8):1871-9. 2. Peddibhotla S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Other Targets |
| Molecular Formula | C21H26Cl3NO2 |
|---|---|
| Molecular Weight | 430.796 |
| Exact Mass | 429.102905 |
| InChIKey | ZAMVVVGRBNNUSR-UHFFFAOYSA-N |
| SMILES | CCOc1cc(CNC2CCCC2)cc(Cl)c1OCc1ccc(Cl)cc1.Cl |
| Benzenemethanamine, 3-chloro-4-[(4-chlorophenyl)methoxy]-N-cyclopentyl-5-ethoxy-, hydrochloride (1:1) |
| N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1) |