ML358

Names

[ Name ]:
ML358

[Synonym ]:
Benzenemethanamine, 3-chloro-4-[(4-chlorophenyl)methoxy]-N-cyclopentyl-5-ethoxy-, hydrochloride (1:1)
N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1)

Biological Activity

[Description]:

ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo.

[References]

References 1. Peddibhotla S, et al. ACS Chem Biol. 2015 Aug 21;10(8):1871-9. 2. Peddibhotla S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆Cl₃NO₂

[ Molecular Weight ]:
430.796

[ Exact Mass ]:
429.102905

Related Compounds

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