1158607-44-3

1158607-44-3 structure

Name: ML358
Chemical Name: N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1)
CAS Number: 1158607-44-3
Molecular Formula: C₂₁H₂₆Cl₃NO₂
Molecular Weight: 430.796
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-01-12 11:44:26
Modify Date: 2022-09-17 11:45:32
ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo.

Name	N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1)
Synonyms	Benzenemethanamine, 3-chloro-4-[(4-chlorophenyl)methoxy]-N-cyclopentyl-5-ethoxy-, hydrochloride (1:1) N-{3-Chloro-4-[(4-chlorobenzyl)oxy]-5-ethoxybenzyl}cyclopentanamine hydrochloride (1:1)

Description	ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo.
References	References 1. Peddibhotla S, et al. ACS Chem Biol. 2015 Aug 21;10(8):1871-9. 2. Peddibhotla S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Other Targets