2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
Modify Date: 2024-01-31 23:40:04
![2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one Structure](https://www.chemsrc.com/caspic/245/1147271-25-7.png)
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one structure
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Common Name | 2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | ||
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| CAS Number | 1147271-25-7 | Molecular Weight | 402.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H22N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-oneJNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1]. |
| Name | 2-Amino-8-(2-morpholin-4-yl-ethoxy)-4-phenyl-indeno[1,2-d]pyrimidin-5-one |
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| Description | JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1]. |
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| Related Catalog | |
| In Vivo | JNJ-40255293 (0.1-10 mg/kg, p.o.) 可以逆转氟哌啶醇 (HY-14538) 诱导的雄性 Balb/c 小鼠僵直症。在雄性 Wistar 大鼠中，JNJ-40255293 也可以剂量依赖性地逆转氟哌啶醇（0.63 mg/kg，皮下注射）诱导的强直性昏厥，增强主动觉醒，显着逆转利血平(HY-N0480)引起的运动活性缺陷[1]。 |
| References |
| Molecular Formula | C23H22N4O3 |
|---|---|
| Molecular Weight | 402.45 |
| Exact Mass | 402.16900 |
| PSA | 90.57000 |
| LogP | 3.16730 |