2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one

Names

[ Name ]:
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one

Biological Activity

[Description]:

JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[In Vivo]

JNJ-40255293 (0.1-10 mg/kg, p.o.) 可以逆转氟哌啶醇 (HY-14538) 诱导的雄性 Balb/c 小鼠僵直症。在雄性 Wistar 大鼠中，JNJ-40255293 也可以剂量依赖性地逆转氟哌啶醇（0.63 mg/kg，皮下注射）诱导的强直性昏厥，增强主动觉醒，显着逆转利血平(HY-N0480)引起的运动活性缺陷[1]。

[References]

[1]. John R Atack, et al. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂N₄O₃

[ Molecular Weight ]:
402.45

[ Exact Mass ]:
402.16900

[ PSA ]:
90.57000

[ LogP ]:
3.16730

Related Compounds

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