2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide

Modify Date: 2025-11-27 17:42:39

2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide structure	Common Name	2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide
	CAS Number	1143020-91-0	Molecular Weight	621.171
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₃ClN₆O₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide

AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM)[1].

Name	2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide
Synonym	More Synonyms

Description	AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM)[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> GHSR
References	[1]. McCoull W, et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014;57(14):6128-6140.

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₇H₃₃ClN₆O₅S₂
Molecular Weight	621.171
Exact Mass	620.164246
LogP	0.61
Index of Refraction	1.645
InChIKey	XWFQFKFKWKWIEW-UHFFFAOYSA-N
SMILES	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1

Benzamide, 2-chloro-N-[[[6-[[3-(4-methyl-1-piperazinyl)propyl]sulfonyl]-2-benzothiazolyl]amino]carbonyl]-5-(4-morpholinyl)-

2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide