2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide

Names

[ Name ]:
2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide

[Synonym ]:
Benzamide, 2-chloro-N-[[[6-[[3-(4-methyl-1-piperazinyl)propyl]sulfonyl]-2-benzothiazolyl]amino]carbonyl]-5-(4-morpholinyl)-
2-Chloro-N-[(6-{[3-(4-methyl-1-piperazinyl)propyl]sulfonyl}-1,3-benzothiazol-2-yl)carbamoyl]-5-(4-morpholinyl)benzamide

Biological Activity

[Description]:

AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> GHSR

[References]

[1]. McCoull W, et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014;57(14):6128-6140.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₇H₃₃ClN₆O₅S₂

[ Molecular Weight ]:
621.171

[ Exact Mass ]:
620.164246

[ LogP ]:
0.61

[ Index of Refraction ]:
1.645

Related Compounds

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