DIF-3
Modify Date: 2024-01-02 11:27:28
DIF-3 structure
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Common Name | DIF-3 | ||
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| CAS Number | 113411-17-9 | Molecular Weight | 272.72500 | |
| Density | 1.24g/cm3 | Boiling Point | 416.9ºC at 760mmHg | |
| Molecular Formula | C13H17ClO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 205.9ºC | |
Use of DIF-3DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1]. |
| Name | 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one |
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| Synonym | More Synonyms |
| Description | DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1]. |
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| Related Catalog | |
| References |
| Density | 1.24g/cm3 |
|---|---|
| Boiling Point | 416.9ºC at 760mmHg |
| Molecular Formula | C13H17ClO4 |
| Molecular Weight | 272.72500 |
| Flash Point | 205.9ºC |
| Exact Mass | 272.08200 |
| PSA | 66.76000 |
| LogP | 3.52280 |
| Vapour Pressure | 1.53E-07mmHg at 25°C |
| Index of Refraction | 1.551 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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The requirement for DIF for prestalk and stalk cell formation in Dictyostelium discoideum: a comparison of in vivo and in vitro differentiation conditions.
Dev. Biol. 127(2) , 296-303, (1988) In Dictyostelium discoideum stalk cell formation is induced by cyclic AMP and differentiation-inducing factor (DIF) when cells are plated in in vitro monolayers (Kay et al., 1979, Differentiation 13: ... |
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Extracellular signals and intracellular transduction pathways regulating Dictyostelium development.
Curr. Opin. Cell Biol. 1(6) , 1132-8, (1989)
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Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum.
Dev. Biol. 140(1) , 182-8, (1990) Stalk cell differentiation in Dictyostelium can be induced by the differentiation-inducing factor, DIF, or by conditions that decrease intracellular pH (pHi). We have investigated whether cytoplasmic ... |
| Differentiation-inducing factor 3 |
| 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone |
| DIF-3 |
| 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Differentiation-inducing factor 3 |
| 1-Hexanone,1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl) |
| Dif-3 (dictyostelium) |