Scyliorhinin II

Modify Date: 2025-08-25 13:12:19

Scyliorhinin II structure	Common Name	Scyliorhinin II
	CAS Number	112748-19-3	Molecular Weight	1851.089
	Density	1.6±0.1 g/cm3	Boiling Point	1817.4±75.0 °C at 760 mmHg
	Molecular Formula	C₇₇H₁₁₉N₂₁O₂₆S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	1052.9±37.1 °C

Use of Scyliorhinin II

Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

Name	2,2'-[(6R,11R,12E,14S,15E,16aS,23E,25S,26E,27aS)-6-({(2S,5S,8S,11S)-2-(4-Aminobutyl)-1,4,7,10,13-pentahydroxy-8-(2-hydroxy-2-iminoethyl)-5,11-bis(hydroxymethyl)-13-[(2S)-1-(L-seryl)-2-pyrrolidinyl]-3,6,9,12-tetraazatrideca-3,6,9,12-tetraen-1-ylidene}amino)-11-{(3S,6S,12S,15S)-3-benzyl-1,4,7,10,13-pentahydroxy-15-[hydroxy(imino)methyl]-12-isobutyl-6-isopropyl-18-thia-2,5,8,11,14-pentaazanonadeca-1,4,7,10,13-pentaen-1-yl}-13,16,24,27-tetrahydroxy-5,21-dioxo-2,3,6,7,11,14,16a,17,18,19,21,22,25,27a-tetradecahydro-1H,5H,10H-dipyrrolo[2,1-j:2',1'-s][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-14,25-diyl]diacetic acid
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Name

2,2'-[(6R,11R,12E,14S,15E,16aS,23E,25S,26E,27aS)-6-({(2S,5S,8S,11S)-2-(4-Aminobutyl)-1,4,7,10,13-pentahydroxy-8-(2-hydroxy-2-iminoethyl)-5,11-bis(hydroxymethyl)-13-[(2S)-1-(L-seryl)-2-pyrrolidinyl]-3,6,9,12-tetraazatrideca-3,6,9,12-tetraen-1-ylidene}amino)-11-{(3S,6S,12S,15S)-3-benzyl-1,4,7,10,13-pentahydroxy-15-[hydroxy(imino)methyl]-12-isobutyl-6-isopropyl-18-thia-2,5,8,11,14-pentaazanonadeca-1,4,7,10,13-pentaen-1-yl}-13,16,24,27-tetrahydroxy-5,21-dioxo-2,3,6,7,11,14,16a,17,18,19,21,22,25,27a-tetradecahydro-1H,5H,10H-dipyrrolo[2,1-j:2',1'-s][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-14,25-diyl]diacetic acid

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More Synonyms

Description	Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
Target	Ki: 2.5 nM (Neurokinin-3 receptor)[1]
In Vitro	Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].
In Vivo	Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].
References	[1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. [2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91.

Density	1.6±0.1 g/cm3
Boiling Point	1817.4±75.0 °C at 760 mmHg
Molecular Formula	C₇₇H₁₁₉N₂₁O₂₆S₃
Molecular Weight	1851.089
Flash Point	1052.9±37.1 °C
Exact Mass	1849.779663
LogP	0.42
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.696
Storage condition	2-8℃

Scyliorhinin II

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Scyliorhinin II

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