Sunitinib D10

Modify Date: 2024-01-12 15:52:00

Sunitinib D10 structure	Common Name	Sunitinib D10
	CAS Number	1126721-82-1	Molecular Weight	408.53500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₇D₁₀FN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sunitinib D10

Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

Name	N-[2-[bis(1,1,2,2,2-pentadeuterioethyl)amino]ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Synonym	More Synonyms

Description	Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> IRE1 Signaling Pathways >> Autophagy >> Mitophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR2:80 nM (IC50) PDGFRβ:2 nM (IC50)
References	[1]. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9. [2]. Ali MM, et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 2011 Mar 2;30(5):894-905.

Molecular Formula	C₂₂H₁₇D₁₀FN₄O₂
Molecular Weight	408.53500
Exact Mass	408.27500
PSA	84.21000
LogP	3.99480

Hazard Codes	Xi

Sunitinib-d10

Sutent-d10

Sunitinib D10

Use of Sunitinib D10

Names

Sunitinib D10 Biological Activity

Chemical & Physical Properties

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