![]() Sunitinib D10 structure
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Common Name | Sunitinib D10 | ||
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CAS Number | 1126721-82-1 | Molecular Weight | 408.53500 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C22H17D10FN4O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Sunitinib D10Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2]. |
Name | N-[2-[bis(1,1,2,2,2-pentadeuterioethyl)amino]ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
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Synonym | More Synonyms |
Description | Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2]. |
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Related Catalog | |
Target |
VEGFR2:80 nM (IC50) PDGFRβ:2 nM (IC50) |
References |
Molecular Formula | C22H17D10FN4O2 |
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Molecular Weight | 408.53500 |
Exact Mass | 408.27500 |
PSA | 84.21000 |
LogP | 3.99480 |
Hazard Codes | Xi |
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Sunitinib-d10 |
Sutent-d10 |