A 804598

Modify Date: 2024-01-04 13:39:26

A 804598 structure	Common Name	A 804598
	CAS Number	1125758-85-1	Molecular Weight	315.37200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₇N₅	Melting Point	N/A
	MSDS	Chinese	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of A 804598

A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.In vitro: A-804598 potently blocked IL-1β release in the THP-1 cells (IC50 of 8.5 nM). A-804598 also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50 of 8.1 nM) with similar potency as in the calcium-influx assay. [1]In vivo: Autoradiographic analysis of coronal rat brain sections revealed that there was specific binding of [3H]-A-804598 throughout the rat brain. High levels of [3H]-A-804598 specific binding were also found in the grey matter of the L4-L6 region of the rat spinal cord. [2]

Name	2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine
Synonym	More Synonyms

Description	A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.In vitro: A-804598 potently blocked IL-1β release in the THP-1 cells (IC50 of 8.5 nM). A-804598 also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50 of 8.1 nM) with similar potency as in the calcium-influx assay. [1]In vivo: Autoradiographic analysis of coronal rat brain sections revealed that there was specific binding of [3H]-A-804598 throughout the rat brain. High levels of [3H]-A-804598 specific binding were also found in the grey matter of the L4-L6 region of the rat spinal cord. [2]
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Cancer
References	[1]. Donnelly-Roberts DL et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology, 2009 Jan, 56(1):223-9. [2]. Able SL et al. Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br J Pharmacol, 2011 Jan, 162(2):405-14.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

Research Areas >> Cancer

References

[1]. Donnelly-Roberts DL et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology, 2009 Jan, 56(1):223-9.

[2]. Able SL et al. Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br J Pharmacol, 2011 Jan, 162(2):405-14.

Molecular Formula	C₁₉H₁₇N₅
Molecular Weight	315.37200
Exact Mass	315.14800
PSA	73.10000
LogP	4.29848
Storage condition	-20℃

A 804598 MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
RIDADR	UN 2811 6.1 / PGIII

N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

A 804598

A-804598

DC Chemicals Limited
China
Product Name: A 804598
Price: $450.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $79/10mM*1mLinDMSO

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A 804598

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