Duocarmycin

Modify Date: 2024-01-08 17:25:30

Duocarmycin structure	Common Name	Duocarmycin
	CAS Number	1116745-06-2	Molecular Weight	463.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆ClN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Duocarmycin

Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) [1].

Name	Duocarmycin

Description	Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
References	[1]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.

Molecular Formula	C₂₆H₂₆ClN₃O₃
Molecular Weight	463.96

Duocarmycin

Use of Duocarmycin

Names

Duocarmycin Biological Activity

Chemical & Physical Properties