Duocarmycin SA
Modify Date: 2025-08-25 18:36:12
Duocarmycin SA structure
|
Common Name | Duocarmycin SA | ||
|---|---|---|---|---|
| CAS Number | 130288-24-3 | Molecular Weight | 477.46600 | |
| Density | 1.53±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C25H23N3O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Duocarmycin SADuocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. |
| Name | (+)-duocarmycin SA |
|---|---|
| Synonym | More Synonyms |
| Description | Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.53±0.1 g/cm3 |
|---|---|
| Molecular Formula | C25H23N3O7 |
| Molecular Weight | 477.46600 |
| Exact Mass | 477.15400 |
| PSA | 122.95000 |
| LogP | 2.74020 |
| Vapour Pressure | 8.82E-25mmHg at 25°C |
| Water Solubility | Practically insoluble (0.03 g/L) (25 ºC) |
| Duocarmycin SA |
| Antibiotic DC 113 |