FERb 033
Modify Date: 2024-01-08 12:12:29
FERb 033 structure
|
Common Name | FERb 033 | ||
|---|---|---|---|---|
| CAS Number | 1111084-78-6 | Molecular Weight | 281.66700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H9ClFNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FERb 033FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1]. |
| Name | 2-Chloro-3'-fluoro-4-[(E)-(hydroxyimino)methyl]-3,4'-biphenyldiol |
|---|---|
| Synonym | More Synonyms |
| Description | FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1]. |
|---|---|
| Related Catalog | |
| Target |
ERβ:4.8 nM (EC50) ERβ:7.1 nM (Ki) |
| In Vitro | FERb 033 (0-100 μM) shows specificity on full-length of estrogen receptor (ESR) in transactivation[2]. FERb 033 (10 nM, 2 h) treatment mildly decreases Ca2+ response in airway smooth muscle (ASM) cells[3]. Cell Viability Assay[2] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: Result: Induced transcriptional activity via full-length receptor on ERE with EC50 values of 0.253 and 0.053 μM for ESR1 and ESR2, respectively. Cell Viability Assay[3] Cell Line: ASM cells Concentration: 10 nM Incubation Time: 2 hours Result: Tended to decrease histamine-elicited Ca2+ response in nonasthmatic human ASM cells but not significantly compared to the control. |
| References |
| Molecular Formula | C13H9ClFNO3 |
|---|---|
| Molecular Weight | 281.66700 |
| Exact Mass | 281.02500 |
| PSA | 73.05000 |
| LogP | 3.36540 |
| InChIKey | LRRMQNGSYOUANY-OMCISZLKSA-N |
| SMILES | C1=CC(=C(C=C1C2=C(C(=C(C=C2)/C=N/O)O)Cl)F)O |
| DMPQ dihydrochloride |
| 2-Pentenoic acid,3-(chlorocarbonyl)-4-methyl-,methyl ester,(E) |
| (E)-3-carbomethoxy-2-(1-methylethyl)prop-2-enoyl chloride |
| (E)-3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime |