DOLASTATIN 10

Modify Date: 2024-01-05 16:14:41

DOLASTATIN 10 structure	Common Name	DOLASTATIN 10
	CAS Number	110417-88-4	Molecular Weight	785.091
	Density	1.1±0.1 g/cm3	Boiling Point	903.6±65.0 °C at 760 mmHg
	Molecular Formula	C₄₂H₆₈N₆O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	500.3±34.3 °C

Use of DOLASTATIN 10

Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

Name	L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R(R),2S],2R[1S,2S,3(R*)]]]
Synonym	More Synonyms

Description	Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.
Related Catalog	Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Natural Products >> Others Peptides Research Areas >> Cancer
Target	Tubulin[1]
In Vitro	Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].
References	[1]. Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31. [2]. Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74(5):962-8. [3]. Brentuximab vedotin. Drugs R D. 2011;11(1):85-95.

Density	1.1±0.1 g/cm3
Boiling Point	903.6±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₆₈N₆O₆S
Molecular Weight	785.091
Flash Point	500.3±34.3 °C
Exact Mass	784.492126
PSA	161.65000
LogP	6.44
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.537
Storage condition	-20°C

RIDADR	UN 3172
Packaging Group	III
Hazard Class	6.1(b)

D-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-D-valinamide

dolastatin 10

From dolabella auricularia (sea hare)

N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-D-valinamide

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Valinamide,N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobut
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

DOLASTATIN 10 suppliers

Price: $626/1mg

Reference only. check more DOLASTATIN 10 price

DOLASTATIN 10

Use of DOLASTATIN 10

Names

DOLASTATIN 10 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms