Bambermycin

Modify Date: 2025-10-23 21:44:56

Bambermycin Structure
Bambermycin structure
 Common Name Bambermycin
CAS Number 11015-37-5 Molecular Weight 1582.583
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C69H107N4O35P Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Bambermycin


Moenomycin complex is a potent transglycosylase inhibitor. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs)[1].

 Names

Name bambermycin
Synonym More Synonyms

 Bambermycin Biological Activity

Description Moenomycin complex is a potent transglycosylase inhibitor. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs)[1].
Related Catalog
Target

Transglycosylase[1]

References

[1]. Cheng TJ, et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):431-6.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C69H107N4O35P
Molecular Weight 1582.583
Exact Mass 1581.661377
PSA 611.69000
LogP 4.81
Index of Refraction 1.615
InChIKey PERZMHJGZKHNGU-UHFFFAOYSA-N
SMILES C=C(CC=C(C)CCC=C(C)C)CCC(C)(C)C=CCCC(C)=CCOC(COP(=O)(O)OC1OC(C(=O)O)C(C)(O)C(OC(N)=O)C1OC1OC(COC2OC(CO)C(O)C(O)C2O)C(OC2OC(C)C(OC3OC(C(=O)NC4=C(O)CCC4=O)C(O)C(O)C3O)C(O)C2NC(C)=O)C(O)C1NC(C)=O)C(=O)O
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QA3020000
CHEMICAL NAME :
Moenomycin
CAS REGISTRY NUMBER :
11015-37-5
LAST UPDATED :
198910

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,740,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,740,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - wakefulness Behavioral - somnolence (general depressed activity)
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,743,1965

 Safety Information

Hazard Statements H413
Risk Phrases 53
RIDADR UN 3077 9 / PGIII
RTECS QA3020000

 Articles28

More Articles
Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Biochem. Pharmacol. 93(2) , 141-50, (2015)

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan ma...

Risk assessment of ciprofloxacin, flavomycin, olaquindox and colistin sulfate based on microbiological impact on human gut biota.

Regul Toxicol Pharmacol 53(3) , 209-16, (2009)

Trace levels of veterinary antibiotics that reside in livestock products may disturb the balance of human intestinal microbiota and impair the colonized barrier function, which is critical to protect ...

Effect of flavophospholipol on conjugation frequency between Escherichia coli donor and recipient pairs in vitro and in the chicken gastrointestinal tract.

J. Antimicrob. Chemother. 58(2) , 359-66, (2006)

To examine the ability of flavophospholipol to inhibit bacterial conjugation between Escherichia coli donor and recipient pairs in vitro and in day-of-hatch chickens.In vitro donor cultures were incub...

 Synonyms

(2R)-3-{[{[(2R,3R,4R,5S,6S)-3-{[(2S,3R,4R,5S,6R)-3-Acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-methyl-5-({(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)carbamoyl]tetrahydro-2H-pyran-2-yl}oxy)tetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-6-carbamoyl-4-(carbamoyloxy)-5-hydroxy-5-methyltetrah
Moenomycine
MOENOMYCIN
menomycin
Bambermycine
BAMBERMYCIN
BAMBERMYCINS
flavophospholipol
Flavomycin
moenomycin a
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