Ganoderic acid Mk
Modify Date: 2024-01-10 14:07:56
Ganoderic acid Mk structure
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Common Name | Ganoderic acid Mk | ||
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| CAS Number | 110024-14-1 | Molecular Weight | 570.76 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H50O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ganoderic acid MkGanoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2]. |
| Name | Ganoderic acid Mk |
|---|
| Description | Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2]. |
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| Related Catalog | |
| Target |
Caspase-3 Caspase-9 |
| In Vitro | Ganoderic acid Mk (0-100 μM, 24 h) 对人类癌细胞表现出比人类正常细胞系更强的细胞毒性[1]。 Ganoderic acid Mk (0-40 μM, 12-48 h) 对HeLa细胞增殖具有剂量依赖性抑制作用[1]。 Ganoderic acid Mk (0-40 μM, 24 h) 诱导HeLa细胞凋亡[1]。 Ganoderic acid Mk (0-40 μM, 24 h) 诱导 ROS 爆发，MMP 减少和 caspase-3, -9 活性增加[1]。 Cell Cytotoxicity Assay[1] Cell Line: Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa) Concentration: 0-100 μM Incubation Time: 24 h Result: Exhibited stronger cytotoxicity to human cancer cells (IC50 values were ranged within 29.8-44.2 µM) than human normal cell lines (IC50 values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively). Cell Viability Assay[1] Cell Line: HeLa cells Concentration: 0, 5, 10, 20, 40 μM Incubation Time: 12, 24, 48 h Result: Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: HeLa cells Concentration: 0, 10, 20, 40 μM Incubation Time: 24 h Result: Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases. |
| References |
| Molecular Formula | C34H50O7 |
|---|---|
| Molecular Weight | 570.76 |