Glutaric acid

Modify Date: 2024-01-01 19:54:57

Glutaric acid Structure
Glutaric acid structure
Common Name Glutaric acid
CAS Number 110-94-1 Molecular Weight 132.115
Density 1.3±0.1 g/cm3 Boiling Point 302.9±15.0 °C at 760 mmHg
Molecular Formula C5H8O4 Melting Point 95-98 °C(lit.)
MSDS Chinese USA Flash Point 151.2±16.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Glutaric acid


Glutaric acid induces oxidative stress in brain of young rats.

 Names

Name glutaric acid
Synonym More Synonyms

 Glutaric acid Biological Activity

Description Glutaric acid induces oxidative stress in brain of young rats.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].
References

[1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 302.9±15.0 °C at 760 mmHg
Melting Point 95-98 °C(lit.)
Molecular Formula C5H8O4
Molecular Weight 132.115
Flash Point 151.2±16.9 °C
Exact Mass 132.042252
PSA 74.60000
LogP -1.04
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.477
Storage condition 2-8°C
Stability Stable. Incompatible with bases, oxidizing agents, reducing agents.
Water Solubility 430 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA3740000
CHEMICAL NAME :
Glutaric acid
CAS REGISTRY NUMBER :
110-94-1
BEILSTEIN REFERENCE NO. :
1209725
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H8-O4
MOLECULAR WEIGHT :
132.13
WISWESSER LINE NOTATION :
QV3VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4684 No. of Facilities: 91 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1827 (estimated) No. of Female Employees: 432 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS MA3740000
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

Iressa
Pentanedioic acid
Irressat
1,5-Pentanedioate
Propane-1,3-dicarboxylic acid
n-Pyrotartaric acid
1,5-Pentanedioic acid
1,3-propanedicarboxylic acid
EINECS 203-817-2
hydrogen glutarate
Glutaric acid
ZD 1839
Gefitinib
1,3-Propanedicarboxylate
MFCD00004410
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