I-OMe-Tyrphostin AG 538
Modify Date: 2025-08-26 12:36:23
I-OMe-Tyrphostin AG 538 structure
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Common Name | I-OMe-Tyrphostin AG 538 | ||
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| CAS Number | 1094048-77-7 | Molecular Weight | 437.19 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12INO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of I-OMe-Tyrphostin AG 538I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM[1]. |
| Name | I-OMe-Tyrphostin AG 538 |
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| Description | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM[1]. |
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| Related Catalog | |
| Target |
IC50: 1 µM (PI5P4Kα)[1] |
| In Vitro | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium[1]. I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk[1]. Cell Viability Assay[1] Cell Line: PANC-1 cells Concentration: 0.1, 1, 10, 1000 µM Incubation Time: 24 hours Result: Cytotoxic to PANC-1 cells in nutrient-deprived medium. Western Blot Analysis[1] Cell Line: PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration: 0.03, 0.3, 3 µM Incubation Time: 1 hour Result: Blocked phosphorylation of IGF-1R, Akt and Erk. |
| References |
| Molecular Formula | C17H12INO5 |
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| Molecular Weight | 437.19 |
| InChIKey | HSRMHXWCTRFVHK-NYYWCZLTSA-N |
| SMILES | COc1cc(C=C(C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O |
| Hazard Codes | Xi |
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