Ezetimibe-d4

Modify Date: 2024-01-04 17:00:33

Ezetimibe-d4 structure	Common Name	Ezetimibe-d4
	CAS Number	1093659-89-2	Molecular Weight	413.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₇D₄F₂NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ezetimibe-d4

Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Name	Ezetimibe-d4
Synonym	More Synonyms

Description	Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Molecular Formula	C₂₄H₁₇D₄F₂NO₃
Molecular Weight	413.45
Exact Mass	413.17400
PSA	60.77000
LogP	4.95330

Ezetimibe-d4