AD57
Modify Date: 2025-08-25 11:01:36
AD57 structure
|
Common Name | AD57 | ||
|---|---|---|---|---|
| CAS Number | 1093380-42-7 | Molecular Weight | 455.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20F3N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AD57AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1]. |
| Name | AD57 |
|---|
| Description | AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Braf |
| In Vitro | AD57 (0.2 nM) 显著抑制了 ptc > dRetMEN2B 在果蝇幼虫中的致死率[1]。 AD57 (0.1 nM) 通过减少 erk 基因剂量提高 ptc > dRetMEN2B 在果蝇中的存活率[1]。 |
| In Vivo | AD57 抑制 RETMEN2 模型中 MEN2B (MZ-CRC-1) 和 MEN2A (TT) 患者来源细胞系的生存能力[1]。 AD57 (20 mg/kg) 在常规小鼠异种移植模型中显著抑制 TT 基肿瘤生长，无明显细胞毒性[1]。 |
| References |
| Molecular Formula | C22H20F3N7O |
|---|---|
| Molecular Weight | 455.44 |
| InChIKey | LEERPLGXOHLQPF-UHFFFAOYSA-N |
| SMILES | CC(C)n1nc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)c2c(N)ncnc21 |