6-NBDG

Modify Date: 2024-01-16 16:51:50

6-NBDG Structure
6-NBDG structure
Common Name 6-NBDG
CAS Number 108708-22-1 Molecular Weight 342.262
Density 1.8±0.1 g/cm3 Boiling Point 729.5±70.0 °C at 760 mmHg
Molecular Formula C12H14N4O8 Melting Point N/A
MSDS N/A Flash Point 395.0±35.7 °C

 Use of 6-NBDG


6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques[1][2].

 Names

Name D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-
Synonym More Synonyms

 6-NBDG Biological Activity

Description 6-NBDG is a fluorescent glucose analogue, it can be used for fluorescence imaging and monitoring glucose transport and uptake. 6-NBDG can be used as a fluorescent probe for detecting macrophage-rich atherosclerotic plaques[1][2].
Related Catalog
In Vitro Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Incubate sample with RPMI (without glucose) containing a final concentration of 200 μM 6-NBDG. 2. Use a curved forcep to embeds sample into the mixture, and stretches the samplet through a drop of agarose (40°C, 20 μL) places on a pre-heated (40°C) glass slide. 3. Gently place another preheated glass slide on the top of sample, so that the whole sample embeds into the agarose-6-NBDG mixture. 4. Take confocal images with a confocal laser scanning microscope (Ex: 471 nm, Em: 500–600 nm)[2].
References

[1]. Hansen TV, et al. Glucose Absorption by the Bacillary Band of Trichuris muris. PLoS Negl Trop Dis. 2016 Sep 2;10(9):e0004971.

[2]. Zaman RT, et al. Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques. PLoS One. 2014 Sep 18;9(9):e108108.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 729.5±70.0 °C at 760 mmHg
Molecular Formula C12H14N4O8
Molecular Weight 342.262
Flash Point 395.0±35.7 °C
Exact Mass 342.081177
LogP -1.01
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.730

 Synonyms

6-Deoxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose
D-Glucose, 6-deoxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-
D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-
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