N-Acetyl-Calicheamicin

Modify Date: 2025-08-25 11:27:47

N-Acetyl-Calicheamicin Structure
N-Acetyl-Calicheamicin structure
 Common Name N-Acetyl-Calicheamicin
CAS Number 108212-76-6 Molecular Weight 1410.39
Density N/A Boiling Point N/A
Molecular Formula C57H76IN3O22S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-Acetyl-Calicheamicin


N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic. Target: AntibacterialN-Acetyl-Calicheamicin is a a derivative of Calicheamicin. Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis. Calicheamicin can interfere with biological processes not simply by cleaving free DNA but also by displacing a DNA-binding protein through competition or modulation of DNA structure.

 Names

Name N-Acetyl-Calicheamicin

 N-Acetyl-Calicheamicin Biological Activity

Description N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic. Target: AntibacterialN-Acetyl-Calicheamicin is a a derivative of Calicheamicin. Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis. Calicheamicin can interfere with biological processes not simply by cleaving free DNA but also by displacing a DNA-binding protein through competition or modulation of DNA structure.
Related Catalog
References

[1]. Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

 Chemical & Physical Properties

Molecular Formula C57H76IN3O22S4
Molecular Weight 1410.39
InChIKey WPDOZYZAJKUVRZ-DPACUSKXSA-N
SMILES CCN(C(C)=O)C1COC(OC2C(OC3C#CC=CC#CC4(O)CC(=O)C(NC(=O)OC)=C3C4=CCSSSC)OC(C)C(NOC3CC(O)C(SC(=O)c4c(C)c(I)c(OC5OC(C)C(O)C(OC)C5O)c(OC)c4OC)C(C)O3)C2O)CC1OC
Storage condition 2-8℃
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