AVP-786

Modify Date: 2025-08-23 23:12:21

AVP-786 Structure
AVP-786 structure
Common Name AVP-786
CAS Number 1079043-55-2 Molecular Weight 277.434
Density 1.1±0.1 g/cm3 Boiling Point 394.9±42.0 °C at 760 mmHg
Molecular Formula C18H19D6NO Melting Point N/A
MSDS N/A Flash Point 116.2±30.2 °C

 Use of AVP-786


Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].

 Names

Name Deudextromethorphan
Synonym More Synonyms

 AVP-786 Biological Activity

Description Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].
Related Catalog
References

[1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer's Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795.

[2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132.

[3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 394.9±42.0 °C at 760 mmHg
Molecular Formula C18H19D6NO
Molecular Weight 277.434
Flash Point 116.2±30.2 °C
Exact Mass 277.231262
LogP 4.11
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.585
InChIKey MKXZASYAUGDDCJ-QNNIAVNKSA-N
SMILES COc1ccc2c(c1)C13CCCCC1C(C2)N(C)CC3

 Synonyms

Morphinan, 17-(methyl-d3)-3-(methyl-d3-oxy)-, (9α,13α,14α)-
UNII:427476LZFT
3-[(2H3)methoxy]-17-[(2H3)methyl]-ent-morphinan
Deudextromethorphan
427476LZFT
CTP-786
DEXTROMETHORPHAN D6
(9α,13α,14α)-17-(2H3)Methyl-3-[(2H3)methyloxy]morphinan
10288
d6-DM
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