Tazofelone

Modify Date: 2024-01-09 12:11:47

Tazofelone Structure
Tazofelone structure
Common Name Tazofelone
CAS Number 107902-67-0 Molecular Weight 321.47700
Density N/A Boiling Point N/A
Molecular Formula C18H27NO2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tazofelone


Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].

 Names

Name tazofelone
Synonym More Synonyms

 Tazofelone Biological Activity

Description Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].
Related Catalog
References

[1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.

[2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8.

 Chemical & Physical Properties

Molecular Formula C18H27NO2S
Molecular Weight 321.47700
Exact Mass 321.17600
PSA 74.63000
LogP 4.04760

 Synonyms

5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidin-4-one
5-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-thiazolidin-4-one
Tazofelone
5-{[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl}-4-thiazolidinone
2,6-di-tert-butyl-4-(1,3-thiazolidin-5-ylmethyl)phenol
LY213829
4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl
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