Tazofelone

Names

[ Name ]:
Tazofelone

[Synonym ]:
5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidin-4-one
5-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-thiazolidin-4-one
Tazofelone
5-{[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl}-4-thiazolidinone
2,6-di-tert-butyl-4-(1,3-thiazolidin-5-ylmethyl)phenol
LY213829
4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl

Biological Activity

[Description]:

Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.

[2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₇NO₂S

[ Molecular Weight ]:
321.47700

[ Exact Mass ]:
321.17600

[ PSA ]:
74.63000

[ LogP ]:
4.04760

Related Compounds

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