107902-67-0

107902-67-0 structure

Name: Tazofelone
Chemical Name: tazofelone
CAS Number: 107902-67-0
Molecular Formula: C₁₈H₂₇NO₂S
Molecular Weight: 321.47700
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-01-16 11:33:07
Modify Date: 2024-01-09 12:11:47
Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].

Name	tazofelone
Synonyms	5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidin-4-one 5-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-thiazolidin-4-one Tazofelone 5-{[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl}-4-thiazolidinone 2,6-di-tert-butyl-4-(1,3-thiazolidin-5-ylmethyl)phenol LY213829 4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl

Description	Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> COX
References	[1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2. [2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8.