4-Hydroxycoumarin

Modify Date: 2025-08-20 13:47:26

4-Hydroxycoumarin structure	Common Name	4-Hydroxycoumarin
	CAS Number	1076-38-6	Molecular Weight	162.142
	Density	1.4±0.1 g/cm3	Boiling Point	352.4±42.0 °C at 760 mmHg
	Molecular Formula	C₉H₆O₃	Melting Point	211-213 °C(lit.)
	MSDS	USA	Flash Point	165.4±20.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Hydroxycoumarin

4-Hydroxycoumarin, a coumarin derivative, is one of the most versatile heterocyclic scaffolds and is frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin derivatives are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors[1].

Name	4-hydroxycoumarin
Synonym	More Synonyms

Description	4-Hydroxycoumarin, a coumarin derivative, is one of the most versatile heterocyclic scaffolds and is frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin derivatives are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Mohammadi Ziarani G, et al. The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions. Mol Divers. 2019 Jan 29. doi: 10.1007/s11030-019-09918-7.

Density	1.4±0.1 g/cm3
Boiling Point	352.4±42.0 °C at 760 mmHg
Melting Point	211-213 °C(lit.)
Molecular Formula	C₉H₆O₃
Molecular Weight	162.142
Flash Point	165.4±20.7 °C
Exact Mass	162.031693
PSA	50.44000
LogP	1.60
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.660
Water Solubility	PRACTICALLY INSOLUBLE

4-Hydroxycoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100000

CHEMICAL NAME :: 2H-1-Benzopyran-2-one, 4-hydroxy-

CAS REGISTRY NUMBER :: 1076-38-6

BEILSTEIN REFERENCE NO. :: 0129768

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H6-O3

MOLECULAR WEIGHT :: 162.15

WISWESSER LINE NOTATION :: T66 BOVJ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,126,1960

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3100000
HS Code	29322980

Precursor 9
CAS#:118-93-4 Ortho-Hydroxyac... CAS#:105-58-8 Ethyl carbonate CAS#:31005-07-9 4-prop-2-enoxyc... CAS#:201230-82-2 carbon monoxide
CAS#:66530-08-3 3-carbethoxy-4-... CAS#:616-38-6 Dimethyl Carbonate CAS#:75-44-5 phosgene CAS#:141-82-2 Malonic acid
CAS#:108-95-2 Phenol
DownStream 10
CAS#:111222-29-8 2H-1-Benzopyran... CAS#:111222-28-7 4-(2-phenylethy... CAS#:10523-48-5 4-HYDROXY-2-OXO... CAS#:10475-15-7 2H-1-Benzopyran...
CAS#:10173-87-2 2,4-diphenyl-4H... CAS#:111222-22-1 9-chlorochromen... CAS#:109797-42-4 4-cyclohex-2-en... CAS#:111222-25-4 4-(BENZYLAMINO)...
CAS#:4865-84-3 2-(1,2-Benzisox... CAS#:66233-72-5 (6-fluoro-benzo...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?

Transl. Oncol. 7(5) , 590-604, (2014)

The use of heat shock protein 90 (Hsp90) inhibitors is an attractive antineoplastic therapy. We wanted to compare the effects of the benzoquinone 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanesp...

Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases.

Acta. Pharm. 65(1) , 53-63, (2015)

The study highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anticancer agents in metastatic breast cancer. Eight compounds, combining the coumarin co...

Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.

J. Med. Chem. 54 , 2331-40, (2011)

Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many ...

4-Monohydroxycoumarin

4-hydroxy-2H-benzopyran-2-one

4-hydroxy-2-chromenone

4-Hydroxy-2H-chromen-2-one

Benzotertonicacid

4-Coumaryl alcohol

4-Hydroxy Coumarin

4-HYDROXYCUMARIN

4-Coumarinol

4-Hydroxy-2H-1-benzopyran-2-one

HydroxyCoumarin

COUMARIN KIT

4-Hydroxycoumarine

4-Hydroxycoumarin

benzotetronic acid

EINECS 214-060-2

MFCD00006856

2H-1-Benzopyran-2-one, 4-hydroxy-

COUMARINOL

4-hydroxy-coumari

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Hydroxycoumarin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Hydroxycoumarin
Price: ￥218.0/100g ￥78.0/25g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxycoumarin suppliers in China
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Hydroxycoumarin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 4-Hydroxycoumarin
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

4-Hydroxycoumarin suppliers

4-Hydroxycoumarin price

4-Hydroxycoumarin

Use of 4-Hydroxycoumarin

Names