Loperamide

Modify Date: 2024-01-02 20:14:52

Loperamide Structure
Loperamide structure
Common Name Loperamide
CAS Number 106900-12-3 Molecular Weight 493.03700
Density N/A Boiling Point N/A
Molecular Formula C29H33ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Loperamide


Loperamide oxide is a prodrug of the effective antidiarrheal loperamide.

 Names

Name 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C29H33ClN2O3
Molecular Weight 493.03700
Exact Mass 492.21800
PSA 69.97000
LogP 5.05940
Water Solubility Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4960200
CHEMICAL NAME :
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)-
CAS REGISTRY NUMBER :
106900-12-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H33-Cl-N2-O3
MOLECULAR WEIGHT :
493.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
172 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

 Safety Information

RIDADR UN 2811 6.1 / PGIII
RTECS TM4960200

 Synonyms

Loperamide N-oxide
Loperamide oxide
trans-N-Oxide of loperamide
Arestal
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