CGP 20712 A

Modify Date: 2024-01-05 10:15:38

CGP 20712 A structure	Common Name	CGP 20712 A
	CAS Number	105737-62-0	Molecular Weight	590.56900
	Density	N/A	Boiling Point	764.8ºC at 760mmHg
	Molecular Formula	C₂₄H₂₉F₃N₄O₈S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	416.3ºC

Use of CGP 20712 A

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

Name	CGP-20712A methanesulfonate salt
Synonym	More Synonyms

Description	CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	IC50: 0.7 nM (β1-adrenoceptor)[1]
In Vitro	In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2].
In Vivo	Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3].
References	[1]. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. [2]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [3]. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8.

Boiling Point	764.8ºC at 760mmHg
Molecular Formula	C₂₄H₂₉F₃N₄O₈S
Molecular Weight	590.56900
Flash Point	416.3ºC
Exact Mass	590.16600
PSA	194.61000
LogP	3.99470
Vapour Pressure	9.69E-23mmHg at 25°C
Storage condition	2-8°C

CGP 20712 A MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors.

Eur. J. Pharmacol. 130 , 137-139, (1986)

CGP 20712 A (1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3- [4-(1-methyl-4-trifluoromethyl-2-imidazolyl) phenoxy]-2-propanol methanesulfonate), a specific beta 1-adrenoceptor antagonist, was test...

Beta-adrenoceptor subtypes in human coronary artery: desensitization of beta 2-adrenergic vasorelaxation by chronic beta 1-adrenergic stimulation in vitro.

J. Cardiovasc. Pharmacol. 25 , 134-141, (1995)

We previously demonstrated that right atrial strips from patients treated with beta 1-selective antagonists exhibit sensitization of beta 2-adrenergic responses in vitro. We also showed that cardiac b...

2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide,methanesulfonic acid

DC Chemicals Limited
China
Product Name: CGP 20712 A
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
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Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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CGP 20712 A

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