DC Chemicals Limited
China
Product Name: CGP 20712 A
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
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Purity: 98.0%
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105737-62-0

105737-62-0 structure

105737-62-0 structure

Name: CGP 20712 A
Chemical Name: CGP-20712A methanesulfonate salt
CAS Number: 105737-62-0
Molecular Formula: C₂₄H₂₉F₃N₄O₈S
Molecular Weight: 590.56900
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2016-07-29 13:11:31
Modify Date: 2024-01-05 10:15:38
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

Name	CGP-20712A methanesulfonate salt
Synonyms	2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide,methanesulfonic acid

Description	CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	IC50: 0.7 nM (β1-adrenoceptor)[1]
In Vitro	In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2].
In Vivo	Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3].
References	[1]. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. [2]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [3]. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8.

Boiling Point	764.8ºC at 760mmHg
Molecular Formula	C₂₄H₂₉F₃N₄O₈S
Molecular Weight	590.56900
Flash Point	416.3ºC
Exact Mass	590.16600
PSA	194.61000
LogP	3.99470
Vapour Pressure	9.69E-23mmHg at 25°C
Storage condition	2-8°C

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