Ac-hMCH(6–16)-NH2

Modify Date: 2025-08-29 11:43:06

Ac-hMCH(6–16)-NH2 Structure
Ac-hMCH(6–16)-NH2 structure
Common Name Ac-hMCH(6–16)-NH2
CAS Number 1053601-50-5 Molecular Weight 1394.73
Density N/A Boiling Point N/A
Molecular Formula C58H99N21O13S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ac-hMCH(6–16)-NH2


Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].

 Names

Name Ac-hMCH(6–16)-NH2

 Ac-hMCH(6–16)-NH2 Biological Activity

Description Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].
Related Catalog
In Vitro Ac-hMCH(6-16)-NH2 exhibits EC50 values of 20 nM and 98 nM for MCH-1R and MCH-2R in aequorin functional assay, respectively[1].
References

[1]. Maria A Bednarek, et al. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. J Biol Chem. 2002 Apr 19;277(16):13821-6.

 Chemical & Physical Properties

Molecular Formula C58H99N21O13S3
Molecular Weight 1394.73
InChIKey GCUCBSVZUDAARP-IHLBVCFISA-N
SMILES CSCCC(NC(=O)C(CS)NC(=O)C(CCCN=C(N)N)NC(C)=O)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCN=C(N)N)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CS)C(N)=O)C(C)C
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