Name | N-Acetylmuramyl-L-Alanyl-D-Isoglutamine-6-O-Stearoyl |
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Synonyms |
(2R)-2-{[(2S)-2-{[2-({(2S,3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-[(stearoyloxy)methyl]tetrahydro-2H-pyran-4-yl}oxy)propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid
Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2 |
Description | L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections[1]. |
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Related Catalog | |
In Vivo | L18-MDP (100 µg;皮下注射;单剂量) 在感染大肠杆菌或克雷白氏肺炎杆菌的小鼠中具有抗感染作用[1]。 L18-MDP (100 µg 或 1000 µg;皮下注射、腹腔注射、静脉注射或口服;单剂量) 提高了感染大肠杆菌小鼠的存活率,改善了感染李斯特菌的小鼠病理组织[1]。 L18-MDP (100 µg 或 200 µg 皮下注射或腹腔注射;一天一次持续 3 天) 提高了感染白色念珠菌小鼠的存活率[1]。 Animal Model: Mice infected with Escherichia coli, Klebsiella pneumoniae or Listeria monocytogenes[1]. Dosage: 100 µg or 1000 µg. Administration: Subcutaneous injection, intraperitoneal injection, intravenous injection or oral gavage; single dose. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. Animal Model: Mice infected with Candida albicans[1]. Dosage: 100 µg or 200 µg. Administration: Subcutaneous injection or intraperitoneal injection; once daily for 3 days. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 1018.5±65.0 °C at 760 mmHg |
Molecular Formula | C37H66N4O12 |
Molecular Weight | 758.940 |
Flash Point | 569.8±34.3 °C |
Exact Mass | 758.467712 |
LogP | 6.48 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.532 |