Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE-6-O-STEAROYL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

60398-08-5

60398-08-5 structure

Name: Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2
Chemical Name: N-Acetylmuramyl-L-Alanyl-D-Isoglutamine-6-O-Stearoyl
CAS Number: 60398-08-5
Molecular Formula: C₃₇H₆₆N₄O₁₂
Molecular Weight: 758.940
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-11-30 14:32:46
Modify Date: 2025-08-25 15:47:12
L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections[1].

Name	N-Acetylmuramyl-L-Alanyl-D-Isoglutamine-6-O-Stearoyl
Synonyms	(2R)-2-{[(2S)-2-{[2-({(2S,3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-[(stearoyloxy)methyl]tetrahydro-2H-pyran-4-yl}oxy)propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2

Description	L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	L18-MDP (100 µg；皮下注射；单剂量) 在感染大肠杆菌或克雷白氏肺炎杆菌的小鼠中具有抗感染作用[1]。 L18-MDP (100 µg 或 1000 µg；皮下注射、腹腔注射、静脉注射或口服；单剂量) 提高了感染大肠杆菌小鼠的存活率，改善了感染李斯特菌的小鼠病理组织[1]。 L18-MDP (100 µg 或 200 µg 皮下注射或腹腔注射；一天一次持续 3 天) 提高了感染白色念珠菌小鼠的存活率[1]。 Animal Model: Mice infected with Escherichia coli, Klebsiella pneumoniae or Listeria monocytogenes[1]. Dosage: 100 µg or 1000 µg. Administration: Subcutaneous injection, intraperitoneal injection, intravenous injection or oral gavage; single dose. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. Animal Model: Mice infected with Candida albicans[1]. Dosage: 100 µg or 200 µg. Administration: Subcutaneous injection or intraperitoneal injection; once daily for 3 days. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue.
References	[1]. Osada Y, et al. Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections. Infect Immun. 1982 Jul;37(1):292-300.

Density	1.2±0.1 g/cm3
Boiling Point	1018.5±65.0 °C at 760 mmHg
Molecular Formula	C₃₇H₆₆N₄O₁₂
Molecular Weight	758.940
Flash Point	569.8±34.3 °C
Exact Mass	758.467712
LogP	6.48
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.532

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