Mometasone

Modify Date: 2024-01-03 17:55:09

Mometasone structure	Common Name	Mometasone
	CAS Number	105102-22-5	Molecular Weight	521.42900
	Density	1.35g/cm3	Boiling Point	586.6ºC at 760mmHg
	Molecular Formula	C₂₇H₃₀Cl₂O₆	Melting Point	220ºC (decomposes)
	MSDS	N/A	Flash Point	308.5ºC

Use of Mometasone

Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].

Name	mometasone
Synonym	More Synonyms

Description	Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vivo	Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3].
References	[1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6. [2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019. [3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90.

Density	1.35g/cm3
Boiling Point	586.6ºC at 760mmHg
Melting Point	220ºC (decomposes)
Molecular Formula	C₂₇H₃₀Cl₂O₆
Molecular Weight	521.42900
Flash Point	308.5ºC
Exact Mass	520.14200
PSA	93.81000
LogP	4.86920
Vapour Pressure	4.47E-18mmHg at 25°C
Index of Refraction	1.603

17α-Hydroxy-21-...

CAS#:83881-08-7

~84%

Mometasone

CAS#:105102-22-5

Literature: Draper, Richard W.; Bin, Hu; McPhail, Andrew T.; Puar, Mohindar S.; Vater, Eugene J.; Weber, Lois Tetrahedron, 1999 , vol. 55, # 11 p. 3355 - 3364

Dexamethasone 9...

CAS#:24916-90-3

Mometasone

CAS#:105102-22-5

Literature: Tetrahedron, , vol. 55, # 11 p. 3355 - 3364

Precursor 2
CAS#:83881-08-7 17α-Hydroxy-21-... CAS#:24916-90-3 Dexamethasone 9...
DownStream 0

9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione

MFCD02683426

Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI)

Mometasone

MOMETOSONE FUROATE

Mometasone

Use of Mometasone

Names

Mometasone Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms