105102-22-5

105102-22-5 structure

Name: Mometasone
Chemical Name: mometasone
CAS Number: 105102-22-5
Molecular Formula: C₂₇H₃₀Cl₂O₆
Molecular Weight: 521.42900
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-06-27 14:46:45
Modify Date: 2025-08-26 00:03:06
Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].

Name	mometasone
Synonyms	9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione MFCD02683426 Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI) Mometasone MOMETOSONE FUROATE

Description	Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vivo	Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3].
References	[1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6. [2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019. [3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90.

83881-08-7

~84%

105102-22-5

24916-90-3

105102-22-5

Literature: Tetrahedron, , vol. 55, # 11 p. 3355 - 3364

Precursor 2
83881-08-7 24916-90-3
DownStream 0