PS 1145 dihydrochloride

Modify Date: 2024-01-05 18:14:04

PS 1145 dihydrochloride structure	Common Name	PS 1145 dihydrochloride
	CAS Number	1049743-58-9	Molecular Weight	395.670
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₃Cl₃N₄O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of PS 1145 dihydrochloride

PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].

Name	N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide,dih ydrochloride
Synonym	More Synonyms

Description	PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IC50: 88 nM (IκB kinase-2)[1]
References	[1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068.

Molecular Formula	C₁₇H₁₃Cl₃N₄O
Molecular Weight	395.670
Exact Mass	394.015503
PSA	74.16000
LogP	6.00480

N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide dihydrochloride

3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, hydrochloride (1:2)

PS-1145 Dihydrochloride

PS 1145 dihydrochloride

Use of PS 1145 dihydrochloride

Names

PS 1145 dihydrochloride Biological Activity

Chemical & Physical Properties

Synonyms