1049743-58-9

1049743-58-9 structure

Name: PS 1145 dihydrochloride
Chemical Name: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide,dih ydrochloride
CAS Number: 1049743-58-9
Molecular Formula: C₁₇H₁₃Cl₃N₄O
Molecular Weight: 395.670
Catalog: Signaling Pathways NF-κB IKK
Create Date: 2018-12-25 13:28:02
Modify Date: 2024-01-05 18:14:04
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].

Name	N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide,dih ydrochloride
Synonyms	N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide dihydrochloride 3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, hydrochloride (1:2) PS-1145 Dihydrochloride

Description	PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IC50: 88 nM (IκB kinase-2)[1]
References	[1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068.