NF023
Modify Date: 2024-01-16 19:46:47
NF023 structure
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Common Name | NF023 | ||
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| CAS Number | 104869-31-0 | Molecular Weight | 1162.88000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H20N4Na6O21S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NF023NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4]. |
| Name | sodium,8-[[3-[[3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid |
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| Synonym | More Synonyms |
| Description | NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4]. |
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| Related Catalog | |
| In Vitro | NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2]. NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4]. |
| In Vivo | NF023 (100 µmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats[3]. |
| References |
| Molecular Formula | C35H20N4Na6O21S6 |
|---|---|
| Molecular Weight | 1162.88000 |
| Exact Mass | 1161.83000 |
| PSA | 492.81000 |
| LogP | 8.34300 |
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| NF 023 |
| ML 786 dihydrochloride |